Patrick Luzi Bader

Dr. med. et phil.-nat.

Psychiatrie und Psychotherapie

Hirnforscher

Ausbildung

Bern 2003-2007

Hochfrequente persönliche Freud’sche Psychoanalyse

Analytiker: Prof. Ch. Müller, Bern

Bern 2003-2007

Ausbildung in Psychoanalyse

Sigmund-Freud-Zentrum

Bern 2006

MD-PhD-Programm der Universität Bern

Doktor der Medizin und Naturwissenschaften (Dr. med. et phil.-nat./MD-PhD) Dissertation: Biophysical characterization of gap junction hemichannels.

Bern 1993-99

Medizinstudium, Universität Bern

Forschungs-, klinische und berufliche Tätigkeiten

2019-2023

Psychiatrisches Ambulatorium Spital Region Oberaargau SRO AG

Oberarzt

2017-2018

Prävention: Drogeninfo Bern Plus (dib+)

Drogenprävention bei Konsumenten von Partydrogen

2017-2018 Mandatsanstellung

Wirtschaft: Coloplast AG (Medizinalprodukte-Firma), Rotkreuz

Ärztlicher Berater

Stanford, CA. New York, NY 2008-2013

Psychiatrische Grundlagenforschung: Stanford und New York University

Postdoctoral Research Fellow; Tutor: Prof. Richard W. Tsien. Forschungsprojekt: Behavioral and electrophysiological exploration of mouse models of human psychiatric diseases.

Bern 2003-07

Klinik: Psychiatrisches Universitätsspital Bern, Universität Bern

Assistenzarzt

Bern 1999-03

Forschung: Institut für Physiologie, Universität Bern

Dissertant

Auszeichnungen

2012-13

Forschungsstipendium für Fortgeschrittene Forschende

Schweizer Nationalfonds und
Schweizerische Stiftung für Medizinisch-Biologische Stipendien

2008-09

Forschungsstipendium für Angehende Forschende

Schweizer Nationalfonds

2002

Asher-Hess Preis

Young Investigators Award, Schweizerische Gesellschaft für Physiologie

Lehrtätigkeiten

New York, NY 2012-2013

New York University

Tutor für Studenten und Dissertanten in Verhaltensexperimenten

Stanford, CA 2010-2011

Stanford University

Tutor für Studenten und Dissertanten in Verhaltensexperimenten

Bern 1999-2003

Universität Bern

Tutor und Prüfungsexperte in Physiologie des Menschen für Medizinstudenten

Wissenschaftliche Publikationen

Portmann T., Yang M., Mao R., Panagiotakos G. Ellegood J., Dolen G., Bader L.P., Gruyter B.A., Goold C., Fisher E., Clifford K. Regarajan P., Kalikhan D., Loureiro D., Saw N.L., Zhengqui Z., Miller M.A., Lerch J.P., Nenkelman M., Shamloo M., Malenka R.C., Crawley N.C., Dolmetsch R.E. (2014) Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome. Cell Rep. 7(4):1077-1092.

Owen S.F., Tuncdemir S.N., Bader P.L., Tirko N., Fishell G. and Tsien R.W. (2013) Oxytocin enhancement of CA1 spike transmission by modulation of fast-spiking interneurons. Nature. 500(7463):458-62.

Bader P.L., Egger M., Weingart R. (1012) Regulation of connexin45 hemichannels mediated by extra- and intracellular calcium. Pflügers Arch. 464(3):249-59.

Faizi M.*, Bader P.L.*, Nay S., Nguyen T.V., Beraki S., Wyss-Coray T., Longo F.M., and Shamloo M. (2012) Thy1- hAPPLond/Swe+ Mouse Model of Alzheimer’s Disease Displays Broad Behavioral Deficits in Sensorimotor, Cognitive and Social Function. Brain and Behavior. 2:142-54

Faizi M., Bader P.L., Tun C., Encarnacion A., Kleschevnikov A., Belichenko P., Saw N., Priestley M., Tsien R.W., Mobley W.C., Shamloo M. (2011) Comprehensive behavioral phenotyping of Ts65Dn mouse model of down syndrome: Activation of β(1)-adrenergic receptor by xamoterol as a potential cognitive enhancer. Neurobiol Dis. 43;397-413.

Bader P.L., Faizi M., Kim L.H., Owen S.F., Tadross M.R., Alfa R.W., Bett G.C., Tsien R.W., Rasmusson R.L., Shamloo M. (2011) A Mouse Model of Timothy Syndrome Recapitulates Triad of Autistic Traits. Proceedings of the National Academy of Science (PNAS). 108(37):15432-7.

Bader P.L., Weingart R. (2006) Pitfalls when examining gap junction hemichannels: interference from volume regulated anion channels. Pflügers Arch. 452: 396-406.

Bader P.L., Weingart R. (2004) Conductive and kinetic properties of connexin45 hemichannels expressed in transfected HeLa cells. J. Membr. Biol. 199: 143-154.

*shared first authorship

Konferenzbeiträge

Bader P.L., Faizi M., Kim L.H., Owen S.F., Bett G.C., Tsien R.W., Rasmusson R., Shamloo M. (2011) A core triad of traits characteristic of autism in a mouse model of Timothy Syndrome. Society for Neuroscience, Washington, DC, USA. Talk.

Priestley M., Bader P.L., Pham J., Valenzuela J., Tsien R.W., Shamloo M. (2010) Automated home-cage behavioral assay for assessment of social behavior in mouse models of autism. Society for Neuroscience Meeting, San Diego, CA, USA. Poster.

Bader P.L., Faizi M., Owen S.F., Tadross M.R., Alfa R.W., Bett G.C., Tsien R.W., Shamloo M., Rasmusson R.L. (2010) Altered social interactions, perseveration, and enhanced fear conditioning in a Timothy Syndrome mouse model of autism. Society for Neuroscience Meeting, San Diego, CA, USA. Poster.

Faizi M., Bader P.L., Encarnacion A., Saw N.L., Priestley M., Patteson B., Lui S., Htun C., Tsien R.W., Mobley W.C., Shamloo M. (2009) Behavioral Phenotyping of Ts65Dn mice as a model of Down Syndrome in a Battery of Behavioral Assays. Society for Neuroscience Meeting, Washington, DC, USA. Poster.

Bader P.L., Wirtz G., Mueller Th., Seifritz E., Jüngling F., Krause Th., Strik W.K. (2005) Unusual psychopathology and early changes in cerebral glucose metabolism in two cases of juvenile frontotemporal dementia. Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde Kongress, Berlin, Germany. Poster.

Bader P.L., Desplantez T., Weingart R. (2003) Kinetic properties of currents carried by mCx45 gap junction channels and hemichannels. International Gap Junction Conference, Cambridge, UK. Poster.

Bader P.L., Weingart R. (2003) Pitfalls in examining connexin hemichannels. In: Proceedings of the 2003 International Gap Junction Conference, p. 41. Cambridge, U.K., Aug. 23-28, 2003. Abstract and poster.

Bader P.L., Weingart R. (2002) Biophysical properties of connexin45 hemichannels. Meeting of Union Schweizer Gesellschaften für Experimentelle Biologie, Lugano, Switzerland. Talk and Poster.

Bader P.L., Weingart R. (2002) Pitfalls in identifying connexin hemichannels. Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Montpellier, France. Poster.

Bader P.L., Weingart R. (2002) Conductive and kinetic properties of connexin45 hemichannels. Annual Meeting of the Swiss Physiological Society, Fribourg, Switzerland. Talk.

Bader P.L., Weingart R. (2002) Conductive and kinetic properties of connexin45 hemichannels. Tag der klinischen Forschung der Universität Bern, Bern, Switzerland. Poster.

Bader P.L., Weingart R. (2001) Electrical properties of connexin45 hemichannels. Meeting of the European Working Group on Cardiac Cellular Electrophysiology, Dresden, Germany. Poster.

Bader P.L., Weingart R. (2001) Biophysical properties of connexin45 hemichannels. Cardiovascular Biology and Clinical Implications Meeting, Interlaken, Switzerland. Poster.